4-Chlorobenzonitrile CAS 623-03-0

Product Name: 4-Chlorobenzonitrile
CAS: 623-03-0
MF: C7H4ClN
MW: 137.57
EINECS: 210-765-4
Melting point: 90-93 °C(lit.)
Boiling point: 223 °C(lit.)
Density: 1,2 g/cm3
Vapor pressure: 6.67hPa at 80.4℃
Refractive index: 1.4530 (estimate)
Fp: 108 °C
Storage temp.: Sealed in dry,Room Temperature

1 kg/bottle or 25 kg/drum or 200 kg/drum or based on customer's requirements. 

1. Pharmaceutical Intermediates
Antimicrobial & Antifungal Agents:
Key precursor for chlorinated heterocycles (e.g., triazoles, pyrimidines) used in drug design.

CNS Drugs: Building block for antidepressants and antipsychotics (e.g., modified phenothiazines).
Anticancer Compounds: Synthesizes kinase inhibitors and targeted therapies (chlorine enhances binding affinity).

2. Agrochemicals
Pesticides & Herbicides: Intermediate for chlorinated neonicotinoids and other crop-protection chemicals.

Fungicides: Improves stability against metabolic degradation.

3. Organic Synthesis
Nitrile Transformations: Converted to:
Carboxylic acids (hydrolysis: –CN → –COOH).
Amines (reduction: –CN → –CH₂NH₂).
Tetrazoles (click chemistry for medicinal chemistry).

Cross-Coupling Reactions: Used in Suzuki-Miyaura or Buchwald-Hartwig reactions to build complex aromatics.

4. Materials Science
Liquid Crystals: Chloro-cyano aromatics enhance thermal stability in display technologies.

Polymer Additives: Modifies dielectric properties in specialty plastics.

1. Temperature: Short-term: Store at room temperature (20–25°C) if used within weeks.

Long-term: Refrigerate (2–8°C) to slow degradation (cold reduces hydrolysis/oxidation).
Avoid freezing (condensation risk upon thawing).

2. Humidity Control: Hygroscopic → Seal in airtight glass or HDPE containers with desiccant packs (silica gel).

For bulk storage, purge with nitrogen (N₂) or argon (Ar) to exclude moisture/oxygen.

3. Light Sensitivity: Use amber glass bottles or wrap in foil (UV light accelerates degradation).