4-Chlorobenzyl cyanide CAS 140-53-4

Product Name: 4-Chlorobenzyl cyanide
CAS: 140-53-4
MF: C8H6ClN
MW: 151.59
EINECS: 205-418-9
Melting point: 25-28 °C(lit.)
Boiling point: 265-267 °C(lit.)
Density: 1.19 g/mL at 20 °C(lit.)
Refractive index: n20/D 1.543
Fp: >230 °F
Storage temp.: Sealed in dry,Room Temperature

1 kg/bottle or 25 kg/drum or 200 kg/drum or based on customer's requirements. 

1. Pharmaceutical Intermediates
Antidepressants & Antipsychotics:
Key precursor for chlorinated aryl-ethylamine derivatives (e.g., SSRIs, tricyclic antidepressants).

Anticonvulsants & Analgesics:
4-Chlorobenzyl cyanide used to synthesize compounds like p-chlorophenyl GABA analogs.

Anticancer Agents: Building block for kinase inhibitors and targeted therapies.

2. Agrochemicals
Pesticides & Herbicides: Intermediate for chlorinated neonicotinoids and other crop-protection chemicals.

Fungicides: Modifies lipophilicity to enhance bioavailability.

3. Dye & Fragrance Industry
Azo Dyes: Forms chlorinated dyes with improved lightfastness.

Synthetic Fragrances: Contributes to floral/musk notes in perfumes.

4. Chemical Synthesis
Nitrile Transformations:
Converted to: Carboxylic acids (via hydrolysis).
Amines (via reduction with LiAlH₄).
Tetrazoles (used in medicinal chemistry).

Cyanoalkylation: Reacts with nucleophiles (e.g., Grignard reagents) to form extended carbon chains.

5. Research Applications
Ligand Design: Chelating agent for metal-catalyzed reactions.

1. Temperature: Short-term: Store at room temperature (20–25°C) if used within weeks.

Long-term: Refrigerate (2–8°C) to slow degradation (cold reduces hydrolysis/nitrile reactivity).

Avoid freezing (condensation risk upon thawing).

2. Humidity Control: Hygroscopic → Seal in airtight glass or HDPE containers with desiccant packs (silica gel).

For bulk storage, purge with nitrogen (N₂) or argon (Ar) to exclude moisture/oxygen.

3. Light Sensitivity: 4-Chlorobenzyl cyanide use amber glass bottles or opaque containers (UV light accelerates degradation).