4-Fluoronitrobenzene CAS 350-46-9

Product Name: 4-Fluoronitrobenzene
CAS: 350-46-9
MF: C6H4FNO2
MW: 141.1
EINECS: 206-502-8
Melting point: 21 °C (lit.)
Boiling point: 205 °C (lit.)
Density: 1.33 g/mL at 25 °C (lit.)
Vapor density: >1 (vs air)
Vapor pressure: 5.5 mm Hg ( 70 °C)
Refractive index: n20/D 1.531(lit.)
Fp: 182 °F
Storage temp.: Sealed in dry,Room Temperature

1 kg/bottle or 25 kg/drum or 200 kg/drum or based on customer's requirements. 

1. Pharmaceuticals
Antibiotics & Antibacterials: 4-Fluoronitrobenzene CAS 350-46-9 used in synthesizing fluoroquinolone antibiotics (e.g., ciprofloxacin derivatives).

Anticancer Agents: Intermediate for kinase inhibitors and other targeted therapies.

CNS Drugs: Building block for antipsychotics and antidepressants.

2. Agrochemicals
Herbicides & Pesticides: Key precursor for fluorinated crop-protection chemicals.

Fungicides: Enhances bioavailability and resistance to degradation.

3. Dyes & Pigments
4-Fluoronitrobenzene CAS 350-46-9 used in azo dyes and fluorescent markers due to its electron-withdrawing properties.

4. Chemical Synthesis
Nucleophilic Aromatic Substitution (SNAr): The –NO₂ group activates the ring for displacement of –F with amines, alkoxides, or thiols.

Cross-Coupling Reactions: 4-Fluoronitrobenzene used in Suzuki-Miyaura or Ullmann reactions to build complex aromatics.

5. Energetic Materials
Occasionally used in explosives research (though less common than nitro derivatives without fluorine).

1. Temperature: Store in a cool, dry place (ideally 2–8°C/36–46°F for long-term storage).

2. Light Sensitivity: Keep in amber glass bottles or opaque containers to prevent photodegradation.

3. Moisture Control: Seal tightly with PTFE-lined caps to avoid hydrolysis.

4. Inert Atmosphere: For extended storage, use nitrogen (N₂) or argon (Ar) purging to prevent oxidation.