Product Name: 4-Fluorophenylacetonitrile
CAS: 459-22-3
MF: C8H6FN
MW: 135.14
EINECS: 207-286-8
Melting point: 86°C
Boiling point: 119-120 °C/18 mmHg (lit.)
Density: 1.126 g/mL at 25 °C (lit.)
Refractive index: n20/D 1.5002(lit.)
Fp: 227 °F
Storage temp.: Inert atmosphere,Room Temperature
|
Item |
Specification |
|
Appearance |
Colorless transparent liquid |
|
Assay |
99%min |
|
Melting point |
86° C |
|
Boiling point |
119-120 °C/18 mmHg (lit.) |
|
Package |
25 kg/drum or 200 kg/drum |
1 kg/bottle or 25 kg/drum or 200 kg/drum or based on customer's requirements.
1. Pharmaceutical Synthesis
Antidepressants & Antipsychotics: Key precursor for fluoro-substituted phenethylamines (e.g., SSRIs like fluoxetine derivatives).
Anticancer Agents: Building block for kinase inhibitors and targeted therapies (fluorine enhances binding affinity).
Antiviral Drugs: 4-Fluorophenylacetonitrile used in synthesizing protease inhibitors (e.g., for HIV/HCV).
2. Agrochemicals
Pesticides & Herbicides: Intermediate for fluorinated neonicotinoids and other crop-protection chemicals.
Fungicides: Improves metabolic stability and lipophilicity of active ingredients.
3. Specialty Chemicals
Liquid Crystals & OLEDs: Fluorinated aromatics enhance thermal/chemical stability in electronic displays.
Dyes & Fragrances: Modifies lightfastness in dyes or adds floral notes to perfumes.
4. Chemical Transformations
Nitrile Reactions: Converted to: Carboxylic acids (hydrolysis: –CN → –COOH).
Amines (reduction: –CN → –CH₂NH₂).
Tetrazoles (click chemistry for drug design).
Fluorophenyl Functionalization: 4-Fluorophenylacetonitrile used in Suzuki couplings or Grignard reactions to build complex molecules.
1. Temperature:
Short-term: Store at room temperature (20–25°C) if used within weeks.
Long-term: Refrigerate (2–8°C) to slow degradation (cold reduces hydrolysis/oxidation).
Avoid freezing (condensation risk upon thawing).
2. Humidity Control:
Hygroscopic → Seal in airtight glass or HDPE containers with desiccant packs (silica gel).
For bulk storage, purge with nitrogen (N₂) or argon (Ar) to exclude moisture/oxygen.
3. Light Sensitivity:
4-Fluorophenylacetonitrile use amber glass bottles or wrap in foil (UV light accelerates degradation).