Product Name: 4-Methoxybenzylchloride
CAS: 824-94-2
MF: C8H9ClO
MW: 156.61
EINECS: 212-540-6
Melting point: −1 °C(lit.)
Boiling point: 117-118 °C14 mm Hg(lit.)
Density: 1.155 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.548(lit.)
Fp: 229 °F
Storage temp.: Inert atmosphere,2-8°C
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Item |
Specification |
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Appearance |
Colorless transparent liquid |
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Assay |
99%min |
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Melting point |
−1 °C(lit.) |
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Boiling point |
117-118 °C14 mm Hg(lit.) |
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Package |
25 kg/drum or 200 kg/drum |
1 kg/bottle or 25 kg/drum or 200 kg/drum or based on customer's requirements.
1. Protecting Group in Organic Synthesis
Alcohol/Amine Protection: Forms PMB ethers (–O-PMB) or PMB amines (–N-PMB), which are stable under acidic/basic conditions but can be removed later with oxidants (e.g., DDQ, CAN) or hydrogenolysis.
2. Pharmaceutical Intermediates
Drug Synthesis: Key precursor for antibiotics (e.g., β-lactams), antivirals, and anticancer agents.
4-Methoxybenzylchloride used to introduce the 4-methoxybenzyl (PMB) group into bioactive molecules.
3. Agrochemicals
Pesticides & Herbicides: Building block for fluorinated or methoxy-substituted active ingredients.
4. Perfumery & Fragrances
Synthetic Aromas: Contributes to floral/fruity notes in perfumes (e.g., anisic or vanilla-like scents).
5. Peptide Chemistry
Carboxyl Group Protection: Forms PMB esters (–COO-PMB), cleavable under mild oxidative conditions.
1. Temperature: Short-term: Store at room temperature (20–25°C) if used within weeks.
2. Long-term: Refrigerate (2–8°C) to slow degradation (cold reduces hydrolysis/oxidation).
Avoid freezing (condensation risk upon thawing).
3. Humidity Control: Hygroscopic → Seal in airtight glass containers with desiccant packs (silica gel).
For bulk storage, purge with nitrogen (N₂) or argon (Ar) to exclude moisture/oxygen.
4. Light Sensitivity: 4-Methoxybenzylchloride use amber glass bottles or wrap in foil (light accelerates decomposition).