| Product Name | Capmatinib hydrochloride |
| CAS | 1865733-40-9 |
| MF | C23H20ClFN6O2 |
| MW | 466.9 |
| Packaging | 1kg/bag, 20kg/drum |
| Application | Capmatinib hydrochloride is an effective, orally active, selective, ATP competitive c-Met kinase inhibitor (IC50=0.13nM).
Capmatinib hydrochloride can inhibit the phosphorylation of c-MET and downstream effector proteins such as ERK1/2, AKT, FAK, GAB1, and STAT3/5 in the c-MET pathway. Capmatinib hydrochloride effectively inhibits the proliferation and migration of c-Met dependent tumor cells, and effectively induces cell apoptosis. It exhibits anti-tumor activity in a tumor mouse model. Capmatinib hydrochloride is mainly metabolized by CYP3A4 and aldehyde oxidase. |
| Storage | Keep in dark place,Sealed in dry,Room Temperature. |