Product name:N-Iodosuccinimide
CAS:516-12-1
MF:C4H4INO2
MW:224.98
Density:2.245 g/cm3
Melting point:202-206°C
Package:1 kg/bag, 25 kg/bag, 25 kg/drum
Property:It is soluble in acetone, methanol, slightly soluble in dioxane, almost insoluble in carbon tetrachloride, ether.
Items |
Specifications |
Appearance |
White crystal |
Purity |
≥99% |
Loss on drying |
≤0.5% |
Water |
≤0.5% |
【Use One】
Mainly used as pharmaceutical intermediates in biopharmaceuticals
【Use Two】
It is used for iodination of ketones and aldehydes in organic synthesis.
【Use Three】
Used in organic synthesis, sulfur oxidation titration reagent, used as a mild iodinating agent, glucosinolate catalyst, etc.
1. Halogenation: NIS is commonly used for the selective iodination of various organic compounds, including olefins, aromatics, and alcohols.
2. Oxidation reaction: It can act as an oxidant in certain reactions, promoting the conversion of alcohols into carbonyl compounds.
3. Synthesis of iodinated compounds: NIS is used to synthesize iodinated drugs and other biologically active molecules.
4. Free Radical Reactions: It can be used in free radical mediated reactions where iodine radicals are generated that can participate in further chemical transformations.
5. Peptide synthesis: NIS is sometimes used in peptide coupling reactions to introduce iodine into the peptide chain.
Store at 2-8°C in a cool, dry and well-ventilated warehouse.
Keep away from fire and heat sources. Avoid direct sunlight.
The package is sealed. It should be stored separately from acids and edible chemicals, and mixed storage should not be avoided.
The storage area should be equipped with suitable materials to contain the leakage.
1. Container: Store NIS in the original container or in a tightly sealed glass or plastic bottle to prevent moisture absorption and contamination.
2. Temperature: Store NIS in a cool, dry place, preferably at room temperature or in a refrigerator. Avoid exposure to high temperatures or direct sunlight.
3. Humidity: Because NIS is sensitive to moisture, it is important to store it in a low humidity environment. If necessary, consider using a desiccant in the storage container.
4. Safety Precautions: Store NIS away from incompatible substances (such as strong reducing agents) and ensure it is kept out of the reach of children and pets.
5. Label: Clearly label containers with the chemical name, concentration, and any relevant hazard information.
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1 kg/bag or 25 kg/drum or 50 kg/drum or according to customers' requirement.
1. Regulatory Compliance: Check and follow local, national, and international regulations regarding the transportation of dangerous goods. NIS may be classified as a hazardous material, so ensure all shipping documents are accurate and complete.
2. Packaging: Use appropriate packaging materials that are compatible with NIS. Typically, this includes using strong, leak-proof containers that can withstand the physical stress of shipping. Ensure that the chemical name and hazard symbol are clearly marked on the container.
3. Label: Clearly label packaging with appropriate hazard warnings, including any relevant safety data (e.g., “oxidizer” or “harmful if swallowed”). Include handling instructions and emergency contact information.
4. Temperature Control: If necessary, ensure that the transport method maintains appropriate temperature conditions to prevent degradation or reaction of the compound.
5. Avoid moisture: Since NIS is sensitive to moisture, please ensure that the packaging is moisture proof. Consider using a desiccant to absorb any moisture during shipping.
6. Transportation method: Choose a reliable method of transportation that minimizes the risk of damage or exposure. Consider using a shipping company that specializes in handling hazardous materials.
7. Emergency Procedures: Include information on emergency procedures in the event of a leak or accident during transportation. This should include the contact information of the emergency team.
8. Training: Ensure that personnel involved in the packaging and transportation of NIS are trained in handling hazardous materials and understand the associated risks.
Yes, N-iodosuccinimide (NIS) is harmful to humans. Here are some key points about its potential harm:
1. Toxicity: NIS is toxic if ingested, inhaled, or absorbed through the skin. It is irritating to the skin, eyes, and respiratory tract.
2. Irritation: Contact with NIS may cause skin and eye irritation. Avoid direct contact and use appropriate personal protective equipment (PPE) when handling.
3. Sensitization: Some people may experience allergic reactions or sensitization after exposure to NIS.
4. Handling Precautions: When using NIS, always use in a well-ventilated area, wear gloves, goggles and protective clothing, and follow all safety guidelines to minimize exposure.
5. First Aid Measures: In case of contact with chemical substances, take appropriate first aid measures, such as flushing the affected area with water and seeking medical attention if necessary.