Product Name: Trimethoprim
CAS: 738-70-5
MF: C14H18N4O3
MW: 290.32
EINECS: 212-006-2
Melting point: 199-203 °C
Boiling point: 432.41°C (rough estimate)
Density: 1.1648 (rough estimate)
Refractive index: 1.6000 (estimate)
Storage temp: 2-8°C
Solubility DMSO: soluble
Pka: 6.6(at 25℃)
Form: white powder
Color: colorless or white
Water Solubility: <0.1 g/100 mL at 24 ºC
Merck: 14,9709
BRN: 625127
| Product Name | Trimethoprim |
| Appearance | White powder |
| Purity | 98.5%-101.0%(BP)；99.0-101.0%(CP) |
| Loss on drying | ≤1.0%(BP)；≤0.5%(USP、CP) |
| Related substances | ≤0.2% |
Antibacterial drugs, the scope of antibacterial is similar to sulfa drugs, combined with sulfa drugs or antibiotics, can greatly improve the efficacy of drugs.
Used in the production of compound trimethoprim, compound cephalexin trimethoprim, Zengxiaoliansu tablets, compound artemisinin tablets.
1. Treatment of bacterial infections: Trimethoprim is commonly used to treat urinary tract infections (UTIs), respiratory tract infections, and certain types of gastrointestinal infections caused by susceptible bacteria.
2. Combination therapy: It is often used in combination with sulfamethoxazole (such as co-trimoxazole) to enhance its antibacterial efficacy. This combination is effective against a wider range of bacteria and is used to treat a variety of infections, including pneumonia, bronchitis, and certain types of gastrointestinal infections.
3. Prevention: Trimethoprim can be used for preventive treatment of patients at high risk of recurrent UTIs.
4. Treatment of Pneumocystis jiroveci pneumonia: It is also used to treat and prevent Pneumocystis pneumonia in immunocompromised patients (such as those with HIV/AIDS).
Store in cold and dry conditions, in a ventilated area away from heating and incompatible materials, sealed and stored.
Trimethoprim should be stored properly to maintain its stability and effectiveness. The following are recommended storage conditions:
1. Temperature: Store trimethoprim at room temperature, usually between 20°C to 25°C (68°F to 77°F). It can be stored in a controlled environment away from extreme heat or cold.
2. Humidity: Please keep it in a dry place, as moisture will affect the stability of the drug.
3. Light Exposure: Protect trimethoprim from light by storing it in its original container, which is usually designed to minimize light exposure.
4. Container: When not in use, ensure container is tightly closed to prevent contamination and degradation.
5. Keep out of reach of children: As with all medications, keep trimethoprim out of reach of children and pets.
Stable. Incompatible with strong oxidizing agents, acids.
Inhale
If inhaled, move the patient to fresh air. If you stop breathing, give artificial respiration.
skin contact
Rinse with soap and plenty of water.
eye contact
Flush eyes with water as a preventive measure.
Ingestion
Never feed anything from the mouth to an unconscious person. Rinse your mouth with water.
When transporting trimethoprim, certain precautions must be taken to ensure its stability and safety. Here are some key considerations to take into account:
1. Temperature Control: Make sure that trimethoprim is kept at the recommended storage temperature (usually room temperature) during transportation. Avoid exposing it to extreme temperatures, either hot or cold.
2. Protect from light: If possible, transport trimethoprim in its original packaging to protect it from light. If the packaging is not light-resistant, consider using an opaque container.
3. Humidity Control: Trimethoprim should be kept in a dry environment during transportation. Avoid storing in areas with high humidity, as moisture will affect the stability of the drug.
4. Safe Packaging: Make sure the container is securely closed and packed to prevent breakage or spillage during shipping. Use cushioning material if necessary.
5. LABEL: Clearly label the package with the contents and any necessary handling instructions to inform transporters of the nature of the material.
6. Avoid contamination: Handle trimethoprim with clean hands and avoid contact with anything that could contaminate it.
7. Regulatory Compliance: Comply with all relevant regulations or guidelines regarding the transportation of pharmaceutical products, including any special requirements for dangerous goods that apply.
By following these precautions, you can help ensure that trimethoprim remains stable and effective during transportation.